https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Induction of caspase-mediated apoptosis in HepG2 liver carcinoma cells using mutagen-antioxidant conjugated self-assembled novel carbazole nanoparticles and in silico modeling studies https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45243 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH4. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:50 AEDT ]]> Induction of caspase-mediated apoptosis in HepG2 liver carcinoma cells using mutagen-antioxidant conjugated self-assembled novel carbazole nanoparticles and in silico modeling studies https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45239 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH4. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:20 AEDT ]]> Enantiospecific adsorption and decomposition of cysteine enantiomers on the chiral cu{421}R surface https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37110 R surface. Although very little difference was observed in the molecular orientation of the two enantiomers as observed with near-edge X-ray absorption fine structure, a large variation in the sulfur bond scission energy was measured using a high-resolution X-ray photoelectron spectroscopy thermal annealing sequence. As a result of this scission process, enantiomers of cysteine molecules completely dissociate into alaninate at temperatures separated by as much as 16 K or 0.06 eV which is one of the largest stereo effects observed on chiral metal surfaces.]]> Tue 18 Aug 2020 13:18:42 AEST ]]> Peptide-Conjugated Micelles Make Effective Mimics of the TRAIL Protein for Driving Apoptosis in Colon Cancer https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54743 Mon 11 Mar 2024 14:25:43 AEDT ]]> Structure-Activity Relationships of Daptomycin Lipopeptides https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40845 Mon 08 Aug 2022 15:39:55 AEST ]]> Cadmium immobilization in the rhizosphere and plant cellular detoxification: role of plant-growth-promoting rhizobacteria as a sustainable solution https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41088 Fri 22 Jul 2022 17:11:19 AEST ]]> The Core-Shell Structure, Not Sugar, Drives the Thermal Stabilization of Single-Enzyme Nanoparticles https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48886 Fri 14 Apr 2023 10:57:45 AEST ]]>